Gelatin capsule

Key knowledge of the gelatin capsule industry: from basic cognition to application practice

Q1: What are the core advantages of gelatin capsules?
As the preferred material for drug and health product carriers, the hydrophilicity and disintegration characteristics of gelatin capsules directly affect the bioavailability of active ingredients. Shaoxing Zhongya Capsule Co., Ltd. has established a pure water treatment system based on the characteristics of the Tianmu Mountain water system to ensure the molecular structure stability of gelatin raw materials during the dissolution process.

Q2: What special functions do empty gelatin capsules assume in formulation research and development?
In the field of new formulation development, empty gelatin capsules exist not only as filling carriers. Data from Shaoxing Zhongya's R&D center show that a specific model of empty capsule shell can withstand a 48-hour integrity test under 80°C/75%RH conditions. This tolerance provides key support for the development of sustained-release preparations.

Q3: What key parameters need to be considered in capsule size selection?
The standardized classification of gelatin capsule size (000#-5#) corresponds to a filling volume range of 0.13-28ml. The engineering laboratory of Shaoxing Zhongya Capsule Co., Ltd. found that when the filling density exceeds 0.9g/cm³, the No. 3 capsule with a progressive expansion design can reduce the material extrusion loss by 37%.

Q4: How does the geographical environment affect the quality of gelatin capsules?
Shaoxing Zhongya Capsule Co., Ltd. is located in the hinterland of Xinchang Tianmu Mountain, and the annual average humidity fluctuation range (60-75%) just matches the optimal curing conditions of gelatin materials. Meteorological monitoring shows that the annual average PM2.5 value in the region is lower than the production environment of 35μg/m³, which keeps the total colony count on the surface of the finished capsules stable at a level of <100CFU/g.

Q5: How can cultural heritage be transformed into manufacturing advantages?
The thousand-year-old medicinal culture of the company's location has catalyzed a unique "herbal level" quality control concept. The formulation engineer extracted the "three-stage maturation control method" from the medicinal material processing techniques of the "Compendium of Materia Medica", which reduced the dispersion coefficient of the freezing force value of the gelatin raw material from the industry average of 8% to 3.2%. This fusion of traditional wisdom and modern technology supports the company in establishing a testing system covering 23 core indicators including pH value, light transmittance, and heavy metal residues.