Do you know the knowledge of hypromellose hollow capsules?

Update:18 Apr 2022

Hypromellose hollow capsules are made of plant compound glue, commonly known as plant-derived hollow capsules. Since 1994, Capsugel, a subsidiary of Pfizer, took the lead in listing hypromellose hollow capsules in the United States. Hypromellose hollow capsules have been favored and recognized by domestic and foreign markets for their excellent product performance and safety. Capsules, put bitter or irritating powders into capsules in doses for easy swallowing. Medicines in capsules are generally powders or granules that are irritating to the esophagus and gastric mucosa, or have bad taste, are easily volatile, are easily decomposed by saliva in the oral cavity, and are easily inhaled into the trachea. These medicines are packed into capsules, which not only protect the medicinal properties of the medicines from being destroyed, but also protect the digestive organs and respiratory tract. Sometimes methylcellulose, calcium alginate, denatured gelatin, PVA and other polymer materials are also used in order to change its solubility or achieve enteric coating. Capsules can mask the bad odor of drugs and are easy to swallow; they can improve the stability and bioavailability of drugs; they can also release drugs at regular intervals, and can make up for the shortcomings of other solid dosage forms, and are widely used.

 

 

The safety and performance of hypromellose hollow capsules are much higher than those of traditional gelatin hollow capsules:
1. The raw materials are derived from plants to avoid the risk of animal-derived diseases.
2. The raw material itself is plant fiber, which is not easy to breed bacteria, and has antibacterial effect.
3. There is no risk of cross-linking reaction. Hypromellose hollow capsules have strong inertness and are not easy to cross-link with aldehyde-containing drugs, making the content safer, more thorough dissolution, and more significant efficacy.
4. Low water content, not easy to react with the contents, suitable for drugs with strong hygroscopicity and moisture sensitivity, especially for various products such as antibacterial and anti-inflammatory drugs, traditional Chinese medicine and high-end health care products.
5. Hypromellose hollow capsules have good stability, and the products are not as harsh as gelatin hollow capsules in terms of storage, transportation, environment, and geographical requirements.

Character and classification:
The capsule is cylindrical, and is a hard and elastic empty capsule that is fitted with a cap and a body. The capsule should be smooth, uniform in color, smooth incision, no deformation, and no odor. This product is divided into three types: transparent, translucent and opaque.
The capsule body section has a tapered edge for smooth encapsulation on high-speed filling machines. The double locking ring system allows the capsules to be pre-locked prior to filling and fully nested together after filling. The design of the capsule also includes ventilation holes to avoid rebound caused by unwanted air pressure inside the capsule during high-speed filling.
There are usually hard capsules and soft capsules. Hard capsules, also known as hollow capsules, are composed of two parts of the cap body; soft capsules are processed into products from film-forming materials and contents at the same time. There are various sizes of capsules, including 000#, 00#, 0#--5# capsules. Capsules can also be coloured and printed for a unique custom look.

Plant capsule is a new type of pharmaceutical excipient with high technology content, high raw material cost, high added value and huge economic benefits. The market potential is particularly broad. Natural consumption has occupied the new world of new medical and pharmaceutical packaging and functional health food packaging. Shandong Hershey Capsule Co., Ltd. actively responds to the national industrial policy, lengthens the product industry chain, realizes large-scale operation, and will be committed to the exploration, innovation and product research of pharmaceutical and health care product packaging materials for a long time. The rapid development of the company establishes a dedicated leading image, and strives to develop into a top supplier in China's plant capsule industry.

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