What are the existing problems with medicinal gelatin?

Update:07 Jun 2022

As a hollow capsule, medicinal gelatin is a special medicinal excipient. It enters the human digestive system together with the medicine and is eventually absorbed by the human body. Therefore, its quality is directly related to the safety of medicine. At present, many key quality problems have also accumulated.

Heavy metal
At present, the limit of the content of heavy metals (chromium, arsenic, mercury, lead, etc.) in the medicinal hollow capsules with gelatin as the raw material is the most concerned issue of the society. Some unscrupulous enterprises use blue alum skin glue instead of medicinal gelatin in production. The bovine bones used for qualified medicinal gelatin should be removed from the skull and vertebrae, which are at risk of infection. Pig skins and cowhide should be fresh skins or frozen skins. control, hygiene management, personnel management, etc.) shall comply with relevant regulations.

Preservatives and Bacteriostatics
Microbiological testing is a general rule that must be carried out for pharmaceutical products, and for gelatin capsules, it is more conducive to the reproduction of microorganisms. Therefore, some enterprises cannot fully control the microbial indicators in the production process due to their poor production environment and sanitation conditions. In order to achieve the purpose of antisepsis, artificially add preservatives and bacteriostatic agents, which is very harmful to the human body.

Beta-agonists
Beta-agonists are commonly used veterinary drugs, their main role is to promote animal growth, reduce fat deposition, and increase lean meat percentage. However, long-term consumption of food containing β-agonist residues will cause great harm to human health. The Ministry of Agriculture of my country has officially banned the use of Clenbuterol as a feed additive. In recent years, clenbuterol, salbutamol, ractopamine and other receptor agonists have also been illegally used in animal production, making law enforcement and detection more difficult. The production materials of gelatin are mostly the skins and bones of cattle, pigs and sheep provided by slaughterhouses. In my country, the extensive use of veterinary drugs and pharmaceutical additives not only causes harm to human health and the environment, but also increases concerns about the quality of medicinal gelatin hollow capsules.

 

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